a person who spoils other people's fun by failing to join in with or by disapproving of their activities. E.g. Sorry to be the wet blanket, and disagree with everyone else, but these liners just don't do it for me.
CRISPRs (clustered regularly interspaced short palindromic repeats) are segments of prokaryotic DNA containing short repetitions of base sequences. Each repetition is followed by short segments of "spacer DNA" from previous exposures to a bacterial virus or plasmid.[2] It is pronounced "crisper".[3] The CRISPR/Cas system is a prokaryotic immune system that confer resistance to foreign genetic elements such as plasmids and phages,[4][5] and provides a form of acquired immunity. CRISPR spacers recognize and cut these exogenous genetic elements in a manner analogous to RNAi in eukaryotic organisms.[2] CRISPRs are found in approximately 40% of sequenced bacteria genomes and 90% of sequenced archaea.[6][note 1] The CRISPR/Cas system has been used for gene editing (adding, disrupting or changing the sequence of specific genes) and gene regulation in species throughout the tree of life.[7] By delivering the Cas9 protein and appropriate guide RNAs into a cell, the organis...
In employment law, constructive dismissal, also called constructive discharge or constructive termination, occurs when an employee resigns as a result of the employer creating a hostile work environment. Since the resignation was not truly voluntary, it is in effect a termination.
1. A person who is a visionary. 2. A company that alters its business strategy and conceives an entirely new business plan. This type of company switches up and forms a new business strategy in order to compete directly or indirectly with competitors. A game changer changes the way that something is done, thought about or made.
set or turn (something) on its end or upside down. "Kitty upended her purse, dumping out all her money" synonyms: overturn , invert , turn over, turn upside down ;
Fig. to stop trying because one is satisfied with one's past achievements. Despite our success, this is no time to rest on our laurels. We rested on our laurels too long. Our competitors took away a lot of our business.
sign up phrasal verb of sign 1 . commit oneself to a period of employment or education or to some other undertaking. "he signed up for a ten-week course" enlist in the armed forces. conclude a business deal. "the company has already signed up a few orders" sign someone up phrasal verb of sign 1 . formally engage someone in employment. e.g. - And Americans are dumbos everywhere. As usual.. -Well, they've created the biggest economy in the world...so if that's dumb...sign me up.
take a leaf out of book Fig. to behave or to do something in a way that someone else would. When you act like that, you're taking a leaf out of your sister's book, and I don't like it! You had better do it your way. Don't take a leaf out of my book. I don't do it well. Hillary Clinton's ambitious education plan takes a page from the left wing of her party, but [...]
Fig. to stop trying because one is satisfied with one's past achievements. Despite our success, this is no time to rest on our laurels. We rested on our laurels too long. Our competitors took away a lot of our business.
Crapshoot Something that is random, not based on skill. People think this refers to an asshole (where your crap shoots out), but it's actually a reference to the dice-rolling game called Craps. E.g.,The stock market is a crap shoot.
› If you put stock in something that someone says or does, you have a high opinion of it: He's been wrong before, so I don't put much stock in what he says any more.